a 01 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2098	A 77-01	A77-01	ALK , TGF-beta/Smad
	A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.		ALK , TGF-beta/Smad
T3031	A 83-01	ALK5 Inhibitor IV,A8301	ALK , TGF-beta/Smad
	A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse fibroblasts into iPSCs. A 83-01 can be used in organoid cult...		ALK , TGF-beta/Smad
T16904	Smurf1-IN-A01	A01	Others
	Smurf1-IN-A01 (A01) is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664 nM). It increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation.		Others
T10442	A 83-01 sodium salt		ALK
	A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and ALK7 induced transcription, respectively [1].		ALK
T69387	NMO-IgG blocker A-01
	NMO-IgG blocker A-01 is a idiotype-specific blocker of neuromyelitis opticaimmunoglobulin g (nmo-igg) binding to aquaporin-4 (aqp4)
T4330	CaCCinh-A01		Chloride channel
	CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).		Chloride channel
T78208	Leramistat	HMC-C-01-A,MBS2320	Mitochondrial Metabolism
	Leramistat (HMC-C-01-A; MBS2320), a mitochondrial complex 1 inhibitor, plays a role in regulating cell and immune metabolism. It is effective in suppressing various conditions, including atopic dermatitis, autoimmune ski...		Mitochondrial Metabolism
T10125	(3R,4R)-A2-32-01		Others
	(3R,4R)-A2-32-01 (compound 2) is a specific caseinolytic protein proteases (ClpP) inhibitor (EC50: 4.5 μM).		Others
T27988	MDG486	BAF IN A01,A01,MDG-486,MDG 486,BAF-IN-A01
	MDG486, an inhibitor of BAF, works by activating latent HIV-1.
T3357	Clascoterone	Cortexolone 17 alpha-propionate,17 alpha-propionate,CB-03-01,Cortexolone 17α-propionate	Androgen Receptor
	Clascoterone (CB-03-01) is a new topical and peripherally selective androgen antagonist.		Androgen Receptor
T24152	HTH-01-091	HTH-01091,HTH01-091,HTH 01-091,HTH 01091	Serine/threonin kinase , Pim , MELK , DYRK , CDK , RIP kinase
	HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be used to study breast cancer.
T25212	CCCI-01	CCCI 01,CCCI01,Centrosome Clustering Chemical Inhibitor-01	Apoptosis
	CCCI-01（Centrosome Clustering Chemical Inhibitor-01） is a centrosome cluster inhibitor. CCCI-01 has anticancer activity, induces apoptosis, and can be used in the study of non-cross-resistant anticancer compounds that bl...		Apoptosis
T2374	HTH-01-015		AMPK
	HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).		AMPK
T8330	BIO-013077-01		TGF-beta/Smad
	BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.		TGF-beta/Smad
T5597	ZT-12-037-01		Serine Protease , Ras
	Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).		Serine Protease , Ras
T22372	MYF-01-37	1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one	Others , YAP
	MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.		Others , YAP
T83657	CCD Lipid01	LP-01	Others
	CCD Lipid01 (LP-01) is a lipid membrane that can be used to deliver biologically active agents .		Others
T15815	LY3295668	AK-01	Aurora Kinase
	LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.		Aurora Kinase
T12400	Peliglitazar racemate	(Rac)-Peliglitazar,(Rac)-BMS 426707-01,BMS 426707-01 racemate	PPAR
	Peliglitazar racemate(BMS 426707-01 racemate) is the racemate of Peliglitazar.Peliglitazar racemate may be used as a potential antidiabetic and anti-obesity agent.		PPAR
T9203	JH-X-119-01		IRAK
	JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.		IRAK